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Product Details for : Helicteres isora

Scarlet colored clawed petals

The different extracts of the roots of Helicteres isora (Family-Sterculiaceae) were tested for

anti-diabetic activity, by glucose tolerance test in normal rats and alloxan induced diabetic rats.

Aqueous ethanol and butanol extracts had shown significant protection and lowered the blood

glucose levels to normal in glucose tolerance test. In alloxan induced diabetic rats the maximum

reduction in blood glucose was observed after 3h at a dose level of 250 mg/kg of body weight. The

percentage protections by aqueous ethanol and butanol extracts were 30 and 48% respectively. In

long term treatment of alloxan induced diabetic rats, the degree of protection was determined by

measuring blood glucose, triglycerides, cholesterol and urea levels on 0,3,5,7 and 10
th day. Both the

extracts showed a significant anti- diabetic activity comparable with that of glibenclamide. The

histopathological studies during the long-term treatment have shown to ameliorate the biochemical

damages caused by alloxan. These results indicate that the Helicteres isora root possess significant

anti – diabetic activity.

INTRODUCTION

Diabetes mellitus is a major disease characterized by derangement in carbohydrate, fat and

protein metabolism, affecting nearly 10% of the population. In the recent past many hypoglycaemic

agents are introduced, still the diabetes and the related complications continue to be a major medical

problem not only in developed countries but also in developing countries. Many Indian medicinal

plants are reported to be useful in diabetes
1, 2. However, search for new anti-diabetic drugs continue.

Helicteres isora Linn. (Family – Sterculiaceae) is a shrub or small tree available in forests

from Bengal to Ceylon. In traditional the root juice is claimed to be useful in diabetes, empyema,

and a favorite cure for snakebite
1, 3. From the roots betulic acid, daucosterol, sitosterol, isorin4 were

isolated. Cucurbitacin B and isocucurbitacin B were isolated and reported to possess cytotoxic

activity
5. The present study was undertaken to verify the claim and evaluate the anti-diabetic

property of the roots H. isora

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